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"Sensing and signaling of methionine metabolism." Metabolites 11.2 (2021): 83.

p62 was found to bind to the NRF2-binding site on KEAP1, thereby competing with NRF2 for KEAP1 binding [84]

Polzer, K

Similarly, a trial published in BMC Nephrology investigating hemodialysis patients with resistant hypertension found that a daily combination of 800 mcg L-methylfolate and 1000 mcg methylcobalamin resulted in statistically significant reductions in both serum homocysteine and blood pressure readings